The prices are very easy to manipulate, and it's hard to find a buyer quickly; most penny stocks you see are hyped as part of "pump and dump" schemes, where someone buys a lot of shares, hypes the stock to the skies, and then sells off their shares to the suckers who believe them.
If you are beginning investor, your best move is to stick with well-established stocks. You will have to invest more, but a company like GE or Home Depot or Verizon is going to be in business a year from now and you can easily sell your shares at any time.
As Hugh Johnson is fond of quoting, "it's time, not timing that makes money in the stock market." You're usually better off buying a strong stock and sticking with it than trying to figure out the best time to sell.
Source: http://boards.straightdope.com/sdmb/showthread.php?t=702246
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